epifriedelinol

Epifriedelinol (EFD) is a natural triterpene compound isolated from the plant *Aster tataricus* L.fil. It is being investigated as a potential therapeutic agent for osteoporosis and other osteoclast-related bone disorders. The compound works by inhibiting osteoclast differentiation and bone resorption through the suppression of the Mitogen-Activated Protein Kinase (MAPK) signaling pathway, specifically targeting ERK, JNK, and p38. This inhibition leads to the downregulation of key transcription factors, including Nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) and Proto-oncogene c-Fos, which are essential for the expression of osteoclast-specific genes. In vitro studies have demonstrated that epifriedelinol reduces bone resorption in a dose-dependent manner without significant cytotoxicity at therapeutic concentrations.

Other names

3-beta-friedelanolepifriedelanol