epimedium total flavonoids

**Epimedium total flavonoids** is an oral traditional Chinese medicine botanical drug candidate formulated as tablets and developed by Zhejiang Jolly Pharmaceutical for primary osteoporosis, including the traditional Chinese medicine syndrome designation of kidney yang deficiency. It is a chemically complex flavonoid-rich extract from *Epimedium* species rather than a single defined small molecule. The candidate is intended to improve bone metabolism by promoting osteoblast-mediated bone formation and suppressing osteoclast formation and bone resorption; preclinical reports have implicated increased transforming growth factor beta 1 and SMAD2 signaling. A registered Phase 1 study, CTR20132865, evaluates oral tolerability and safety in healthy participants and seeks to establish a safe dose range for subsequent clinical development. ([synapse.zhihuiya.com](https://synapse.zhihuiya.com/drug/22be8090639449c594db6d24c8f6a480))

Other names

Epimedium total flavonoid tabletsEpimedium flavonoids tabletsyinyanghuo total flavonoid tablets淫羊藿总黄酮片