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Epirubicin + Vindesine
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
The combination of epirubicin and vindesine is a chemotherapy regimen used primarily in the treatment of advanced breast cancer. This combination has been studied in several clinical trials to evaluate its efficacy compared to single-agent therapy or other combinations. Epirubicin is an anthracycline topoisomerase II inhibitor, which is a 4'-epi-isomer of doxorubicin. It works by interfering with DNA synthesis and function[3]. Vindesine is a vinca alkaloid that stops cancer cells from dividing by disrupting microtubule formation, ultimately leading to cell death[4].
- Other names
- EV (Epirubicin-Vindesine)
02
Targets
DNATOP2A (DNA topoisomerase II)TUBB (Tubulin (alpha and beta subunits))
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