Drug intelligence / Profile preview

Epirubicina Liposomal

Development stage
Unknown
Lead developer
Salud Pharma
Modality
Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
Administration
Intravenous
01

Overview

Liposomal epirubicin is an anthracycline chemotherapy agent encapsulated within liposomes. It functions primarily by intercalating between DNA base pairs and inhibiting the enzyme topoisomerase II, which prevents DNA replication and transcription, ultimately leading to cell death. The liposomal formulation is intended to improve the therapeutic index of epirubicin by enhancing drug delivery to tumor sites via the enhanced permeability and retention (EPR) effect while minimizing exposure to healthy tissues, thereby reducing the risk of cardiotoxicity and other systemic side effects. It is distributed by Salud Pharma for the treatment of breast cancer and other oncology indications where anthracyclines are standard of care.

Brand names
Epirubicina Liposomal
Other names
Liposomal epirubicinEpirubicin (liposomal formulation)
02

Targets

TOP2A (DNA topoisomerase II)DNA

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