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EpiSmart
- Development stage
- Unknown
- Lead developer
- Epion Therapeutics
- Modality
- Implantable Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Ophthalmic, Topical
01
Overview
**EpiSmart** is an investigational epithelium-on corneal cross-linking drug-device combination developed by Epion Therapeutics for keratoconus and ectatic corneal disease. The system integrates EpiPrep corneal drug-delivery applicators, RiboStat ophthalmic riboflavin and sodium iodide formulation, and a UVA light device. Topically delivered riboflavin is photoactivated by UVA light to generate singlet oxygen and induce corneal stromal collagen cross-links, thereby strengthening the biomechanically weakened cornea while preserving the corneal epithelium. EpiSmart completed patient follow-up in its pivotal Phase 3 keratoconus program in June 2026 and remains investigational. ([epiontx.com](https://www.epiontx.com/epismart))
- Brand names
- EpiSmart
- Other names
- EpiSmart CXL systemEpiSmart cross-linking systemEpiSmart Epithelium-On Cross-Linking System
02
Targets
COL (Collagen type XXI alpha 1 chain)
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