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EpiSpray
- Development stage
- Preclinical
- Lead developer
- HypoSpray Pharma
- Modality
- Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems
- Administration
- Transdermal
01
Overview
EpiSpray is a needle-free, transdermal formulation of epinephrine developed by HypoSpray Pharma (formerly Transdermal Delivery Solutions Corp.) for the emergency treatment of severe allergic reactions, including anaphylaxis. The product utilizes a proprietary transdermal delivery platform that applies a liquid spray to intact skin, using Generally Regarded As Safe (GRAS) carriers to facilitate rapid systemic absorption of the active ingredient. As a non-selective adrenergic agonist, the epinephrine in EpiSpray stimulates alpha- and beta-adrenergic receptors to counteract the physiological effects of anaphylaxis, such as vasodilation and bronchoconstriction. The technology is designed as a non-invasive alternative to traditional intramuscular auto-injectors.
- Brand names
- EpiSprayEpi Mist HypoSpray Epinephrine
- Other names
- epinephrineadrenalineEpi Mist
02
Targets
ADRA1A (α1A)ADRA2A (α2A)ADRB1 (β1)ADRB2 (β2)
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