epoxidized alpha-tocotrienol

Epoxidized alpha-tocotrienol (also known as mono-epoxy-tocotrienol-alpha or MeT3α) is a chemically modified derivative of alpha-tocotrienol, a member of the vitamin E family, featuring an epoxide moiety on its polyisoprene side chain. Developed by researchers at the Karolinska Institutet, Stockholm University, and the Polish Academy of Sciences, this compound has been investigated for its therapeutic potential in diabetic wound healing and the management of diabetic complications. In preclinical models, such as the db/db diabetic mouse model, topical application of epoxidized alpha-tocotrienol significantly enhances wound closure, stimulates fibroblast migration, and promotes angiogenesis (endothelial capillary tube formation). Mechanistically, the compound improves mitochondrial function by increasing basal and reserve respiratory capacity while reducing mitochondrial superoxide production and oxidative stress. It also modulates gene expression, upregulating key growth factors like vascular endothelial growth factor A (VEGFA) and platelet-derived growth factor subunit B (PDGFB), while downregulating lanosterol synthase.

Other names

MeT3αepoxidized α-tocotrienolmono-epoxy-tocotrienol-alphamono-epoxy-tocotrienol-α