Drug intelligence / Profile preview

eppikajutsuto

Development stage
Unknown
Lead developer
Tsumura
Administration
Oral
01

Overview

Eppikajutsuto (also known as Yue-Bi-Jia-Zhu-Tang) is a traditional Japanese Kampo medicine composed of six botanical and mineral ingredients: Ephedra Herb, Gypsum, Atractylodes Rhizome, Jujube, Licorice, and Ginger. It is traditionally used to treat conditions characterized by inflammation, edema, and heat, such as arthritis, nephritic syndrome, and eczema. In recent clinical research, it has been investigated for its potential to mitigate acute adverse reactions, particularly fever, following COVID-19 vaccination. The formula is thought to exert its effects through anti-inflammatory and antipyretic mechanisms, likely involving the modulation of cytokine production (e.g., IL-6, TNF-alpha) and prostaglandin synthesis.

Brand names
Tsumura Eppikajutsuto Extract Granules
Other names
Yue-Bi-Jia-Zhu-TangYuebijiazhuangtang越婢加朮湯
02

Targets

PGE2 (Prostaglandin E2)TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)AR (Adrenergic receptors)

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