Drug intelligence / Profile preview

eprinomectin

Development stage
Unknown
Lead developer
Navana Pharmaceuticals
Modality
Small Molecules
Administration
Topical
01

Overview

Navaprin Vet is a veterinary antiparasitic medication containing eprinomectin, a semi-synthetic macrocyclic lactone of the avermectin family. Developed by Navana Pharmaceuticals, it is formulated as a topical pour-on solution for the treatment and control of internal and external parasites in livestock, such as beef and dairy cattle, as well as domestic animals like cats. Eprinomectin acts by selectively binding with high affinity to glutamate-gated chloride ion channels in invertebrate nerve and muscle cells, leading to hyperpolarization, paralysis, and death of the parasites. It is highly effective against gastrointestinal roundworms, lungworms, grubs, sucking and biting lice, mites, and horn flies, offering a wide safety margin and zero withdrawal periods for meat and milk.

Brand names
Navaprin Vet
Other names
4''-deoxy-4''-epiacetylamino-avermectin B14''-epi-acetylamino-4''-deoxy-avermectin B1aeprinomectin B1aeprinomectin B1b
02

Targets

GluCl (Glutamate-gated chloride channel)

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