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Er-Zhi-Wan
- Development stage
- Unknown
- Lead developer
- Longhua Hospital Shanghai University of Traditional Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Er-Zhi-Wan (also known as Erzhi Pill or Two Solstices Pill) is a classic Traditional Chinese Medicine (TCM) formula consisting of two herbal ingredients: Nu Zhen Zi (Fructus Ligustri Lucidi) and Han Lian Cao (Herba Ecliptae), typically in a 1:1 ratio. Traditionally used to nourish liver and kidney yin, it is clinically investigated for various conditions including primary biliary cholangitis (PBC), osteoporosis, menopausal syndrome, and age-related muscle and bone loss. In a clinical trial sponsored by Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Er-Zhi-Wan is evaluated in combination with Shi-Xiao-San Powder and ursodeoxycholic acid (UDCA) for the treatment of stage II-III primary biliary cholangitis.
- Other names
- Erzhi PillErzhi PillsErzhi WanTwo Solstices PillTwo Ultimate Pill
02
Targets
AR (Adrenergic receptors)CASP8 (Caspase-8)POLB (DNA polymerase beta)EGFR (Epidermal growth factor receptor)ESR1 (ERα)PREP (Prolyl Oligopeptidase)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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