Drug intelligence / Profile preview

erbstatin

Development stage
Unknown
Modality
Small Molecules
01

Overview

**Erbstatin** is a synthetic *tyrosine kinase inhibitor* originally identified as a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase activity. It is typically used for research purposes rather than as a marketed pharmaceutical. Erbstatin blocks EGFR autophosphorylation and associated downstream signaling, thereby interfering with cellular proliferation and survival signals. Its primary applications are in cellular and biochemical studies investigating EGFR signaling pathways, cancer biology, and tyrosine kinase mechanisms.

Other names
erbstatin
02

Targets

TOP1 (DNA Topoisomerase I)TOP2A (DNA topoisomerase II)ERBB2 (Erb-b2 receptor tyrosine kinase 2)SFK (SRC family kinases)PKA (Cyclic amp-dependent protein kinase)

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