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Drug intelligence / Profile preview
erchen tang
- Development stage
- Unknown
- Lead developer
- China Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Erchen Tang (also known as Erchen Decoction) is a foundational Traditional Chinese Medicine (TCM) formula first recorded in the 'Tai Ping Hui Min He Ji Ju Fang.' It is traditionally indicated for 'damp-phlegm' syndromes, characterized by cough with abundant white sputum, nausea, and chest congestion. The formula typically comprises four primary herbs: *Pinellia ternata* (Banxia), *Citrus reticulata* (Chenpi), *Poria cocos* (Fuling), and *Glycyrrhiza uralensis* (Gancao). Modern pharmacological research indicates that Erchen Tang exerts anti-inflammatory, immunomodulatory, and metabolic-regulating effects. It has been shown to inhibit the PI3K/AKT/NF-κB signaling pathway, thereby reducing the expression of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). Clinically, it is investigated for its efficacy in treating community-acquired pneumonia and hyperlipidemia, often as part of integrated therapy.
- Other names
- Erchen DecoctionEr Chen TangTwo-Cured Decoction
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)IL-6 (Interleukin 6)PIK3CA (Phosphoinositide 3-kinase alpha)PIK3R1 (Phosphatidylinositol 4-phosphate 3-kinase regulatory subunit alpha)SRC (Proto-oncogene tyrosine-protein kinase Src)TNFA (Tumor necrosis factor alpha (soluble))AKT (RAC-alpha serine/threonine-protein kinase)NF-κBPI3K (Phosphoinositide-3-kinase regulatory subunit 6)
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