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Drug intelligence / Profile preview
erepoxen
- Development stage
- Phase 2
- Lead developer
- Pharmsynthez
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
- Administration
- Subcutaneous
01
Overview
ErepoXen is a **polysialylated form of recombinant human erythropoietin (EPO)** developed to treat anemia, particularly in pre-dialysis patients with chronic kidney disease. The addition of polysialic acid extends the half-life of EPO, enabling less frequent dosing (up to once a month), and is intended to reduce immunogenicity and side effects compared to standard erythropoietin-based therapies. Its mechanism of action is **agonism of the erythropoietin receptor**, stimulating erythropoiesis (red blood cell production) in the bone marrow. ErepoXen uses Xenetic Biosciences’ PolyXen® technology and has been developed in collaboration with Serum Institute of India and SynBio. It is currently in Phase 2/3 development for anemia[2][4][5][6][7][8].
- Brand names
- ErepoXen
- Other names
- ErepoXenpolysialylated erythropoietinEpolongpolysialic EPOpolysialic erythropoietin
02
Targets
Erythropoietin Receptor
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