ergosterol peroxide

Ergosterol peroxide is a naturally occurring steroid derivative and small molecule isolated from various medicinal fungi, most notably *Ganoderma lucidum* (Reishi), as well as yeast, lichens, and sponges. It exhibits a broad spectrum of biological activities, including potent anticancer, anti-inflammatory, antiviral, and antimycobacterial properties. Mechanistically, it has been identified as an inhibitor of glutaminase 1 (GLS1), which disrupts cancer cell metabolism by blocking the conversion of glutamine to glutamate, and as an inhibitor of the sodium/taurocholate cotransporting polypeptide (NTCP), which is a key entry receptor for hepatitis B and D viruses. Preclinical research, primarily conducted by academic institutions such as Qiqihar Medical University and National Chiao Tung University, has demonstrated its efficacy in murine models of triple-negative breast cancer and liver cancer. The compound has shown metabolic stability and a favorable safety profile in animal studies, with no signs of toxicity at doses up to 500 mg/kg.

Other names

5α,8α-epidioxyergosta-6,22-dien-3β-ol5,8-epidioxyergosterolergosterol 5,8-peroxide