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Santa herba extract is a flavonoid-rich botanical preparation derived from the leaves of Eriodictyon californicum, commonly known as yerba santa. Traditionally used for respiratory conditions, recent research has focused on its potential in weight management and metabolic health. The extract contains high levels of flavonoids such as homoeriodictyol, eriodictyol, and sterubin. Clinical studies suggest that Santa herba extract may reduce body weight and fat mass in overweight and obese individuals by modulating appetite-related hormones like leptin and improving eating behavior. Mechanistically, it exhibits antioxidative properties and appears to act as an antagonist at the adenosine A2A receptor (ADORA2A), which may promote lipolysis in adipocytes. The product is marketed both as a dietary supplement for weight management and supportive therapy for asthma or bronchial diseases[3][4][5][6][8].
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