Drug intelligence / Profile preview

erlotinib + capmatinib + enfortumab vedotin

Development stage: Unknown
Modality: Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules
Administration: Oral, Intravenous

Overview

This is a combination of three distinct cancer medications: - **Erlotinib (Tarceva)**: A tyrosine kinase inhibitor that works by blocking the epidermal growth factor receptor (EGFR), which is involved in cancer cell growth and survival. It is used to treat non-small cell lung cancer (NSCLC) with specific EGFR mutations and pancreatic cancer. - **Capmatinib**: A targeted therapy for NSCLC. - **Enfortumab vedotin (Padcev)**: An antibody-drug conjugate used in cancer treatment.

Brand names: Tarceva + capmatinib + Padcev

Targets

EGFR (Epidermal growth factor receptor)MET (Mesenchymal-epithelial transition factor receptor)PVRL4 (Nectin cell adhesion molecule 4)

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