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erlotinib + everolimus

Development stage: Unknown
Lead developer: Novartis
Modality: Small Molecules
Administration: Oral

Overview

A combination therapy consisting of erlotinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, and everolimus, a mammalian target of rapamycin (mTOR) inhibitor. This dual-targeting approach aims to inhibit both EGFR signaling and the downstream PI3K/AKT/mTOR pathway to enhance anti-tumor efficacy and potentially overcome resistance mechanisms. The combination has been studied in various cancer types including non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), and pancreatic cancer.

Targets

EGFR (Epidermal growth factor receptor)Mechanistic target of rapamycin complex 1

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