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erlotinib + pazopanib
- Development stage
- Unknown
- Lead developer
- Novartis
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy consisting of erlotinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, and pazopanib, a multi-targeted tyrosine kinase inhibitor of vascular endothelial growth factor receptors (VEGFR). This dual pathway blockade approach targets both EGFR and angiogenesis pathways simultaneously to inhibit tumor growth. The maximum tolerated dose is pazopanib 600 mg plus erlotinib 150 mg once daily.
02
Targets
VEGFR2 (Vascular endothelial growth factor receptor 2)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)FGFR3 (Fibroblast growth factor receptor 3)EGFR T790M (Epidermal growth factor receptor T790M mutant)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR3 (Vascular endothelial growth factor receptor 3)
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