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Ermiao Wan
- Development stage
- Unknown
- Lead developer
- Southern Medical University
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Ermiao Wan (also known as Ermiao San or Two Marvels Pill) is a classic traditional Chinese medicine (TCM) herbal formula composed of a 1:1 ratio of *Cortex Phellodendri* (Huang Bai) and *Rhizoma Atractylodis* (Cang Zhu). It is widely used in China to clear heat, resolve dampness, and treat inflammatory-related conditions such as gout, hyperuricemia, atopic dermatitis, and pelvic inflammatory disease. Modern pharmacological studies suggest that Ermiao Wan exerts its therapeutic effects by inhibiting xanthine oxidase and xanthine dehydrogenase to lower uric acid levels, as well as modulating inflammatory pathways such as NF-κB, MAPK, and EGFR/AKT signaling.
- Other names
- EMWErmiao PillErmiao SanTwo Marvels PillTwo Marvels PowderTwo-Marvel Pill
02
Targets
XO (Xanthine Oxidoreductase)
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