ERr 731

ERr 731 is a standardized extract of the root of *Rheum rhaponticum* (Siberian rhubarb), developed as a nonhormonal therapy primarily for the relief of menopausal symptoms—particularly hot flashes, night sweats, anxiety, mood disturbances, and related symptoms. ERr 731 has been used in Europe since the 1990s and has an established safety profile supported by clinical trials and postmarketing surveillance. Its principal mechanism of action is selective agonism of the estrogen receptor beta (ERβ), without significant activation of estrogen receptor alpha (ERα), resulting in relief of menopausal symptoms without the risks typically associated with conventional hormone therapies. The extract is contraindicated in individuals with known or suspected estrogen-dependent cancers. ERr 731 is distributed under various trade names in Europe and North America and is available as a nonprescription product in multiple countries[1][2][3][4][5].

Brand names

Phytoestrol Nfemi-logesEstrovera

Other names

Siberian rhubarb extractRheum rhaponticum extract