Drug intelligence / Profile preview

eschscholzia californica extract

Development stage
Unknown
Administration
Oral
01

Overview

**Eschscholzia californica extract** is an herbal preparation derived from the aerial parts (and sometimes roots) of the California poppy, a plant native to western North America. The extract contains a range of alkaloids, notably benzylisoquinoline alkaloids such as protopine, allocryptopine, californidine, and pavine, which are thought to modulate gamma-aminobutyric acid (GABA) receptors in the central nervous system. The extract is traditionally used as a dietary supplement for its **sedative, anxiolytic, mild analgesic, antispasmodic, and hypnotic** effects[1][2][3][4][5][6]. It is marketed primarily to promote sleep, reduce nervous tension, and ease anxiety or mild pain. Scientific evidence is limited but suggests possible sedative and anxiolytic effects, likely via GABAergic modulation. It is non-narcotic and considered gentle enough for children, but it may interact with some pharmaceuticals, particularly blood pressure drugs and anticoagulants[2][6].

Other names
eschscholzia californicacalifornia poppy extractgolden poppycalifornia sunlightcup of goldflame floweramapola de californiayellow poppypavot d’amériquepavot d’orpavot de californie
02

Targets

GABRA6 (Gamma-aminobutyric acid receptor subunit alpha-6)HTR7 (5-hydroxytryptamine receptor 7)ButyrylcholinesteraseHTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

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