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escitalopram + fluoxetine + paroxetine + sertraline
- Development stage
- Unknown
- Lead developer
- Lundbeck
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This is a combination of four distinct selective serotonin reuptake inhibitors (SSRIs) that are typically prescribed individually, not as a fixed-dose combination product. Each medication works by inhibiting serotonin reuptake in the brain but has unique pharmacological properties. Escitalopram is highly selective with potential allosteric binding at SERT, fluoxetine has a long half-life, paroxetine has anticholinergic properties, and sertraline has additional dopamine transporter inhibitory effects.
02
Targets
SERT allosteric site (Serotonin transporter allosteric site)SIGMAR1 (Sigma non-opioid intracellular receptor 1)CYP2D6 (Cytochrome P450 2D6)DAT (Dopamine plasma membrane transport protein)CYP2C19 (Cytochrome P450 2C19)
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