esketamine + pulsed radiofrequency

This therapeutic approach combines the NMDA receptor antagonist **esketamine** with **pulsed radiofrequency (PRF)** for the treatment of acute or subacute zoster-associated trigeminal neuralgia (ZRTN). Esketamine, the S-enantiomer of ketamine, provides analgesic effects by non-competitively inhibiting NMDA receptors, which are involved in central sensitization and chronic pain. Pulsed radiofrequency is a minimally invasive neuromodulation technique that delivers high-frequency electrical current in short bursts to the affected nerve (in this case, the trigeminal nerve or Gasserian ganglion), aiming to alter pain signaling without causing significant thermal tissue destruction. This combination is being investigated by **Beijing Tiantan Hospital** to improve pain relief and safety outcomes compared to standard treatments or PRF alone.

Other names

esketamine combined pulsed radiofrequencyEsketamine + PRFPRF-Beijing Tiantan Hospital-trigeminal neuralgia-herpes zoster