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ESN0115 is a preclinical cell therapy candidate developed by Beijing Yisheng Biotechnology (Essentia Biosciences) for the treatment of diabetes. The therapy utilizes 3D bioprinting technology to encapsulate islet cells within advanced biomaterials, creating a protective microenvironment. This encapsulation strategy is designed to shield the transplanted islet cells from the host's immune system and the harsh post-transplantation environment, thereby improving cell survival and functional longevity. By facilitating the successful engraftment of insulin-producing cells, ESN0115 aims to restore endogenous glycemic control in patients undergoing islet cell transplantation.
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