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esomeprazole + amoxicillin + levofloxacin + tetracycline
- Development stage
- Preclinical
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy used for Helicobacter pylori (H. pylori) eradication, particularly as a potential salvage therapy after failure of standard treatments. This regimen combines a proton pump inhibitor (esomeprazole) with three antibiotics (amoxicillin, levofloxacin, and tetracycline) to overcome antibiotic resistance in H. pylori infections.
02
Targets
Bacterial RibosomeDNA gyrasePBP (Penicillin-binding protein family)Topo IV (Bacterial Topoisomerase IV)ATP4A (Potassium–transporting ATPase alpha chain 1)
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