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esomeprazole + argon plasma coagulation
- Development stage
- Unknown
- Lead developer
- HSK Wiesbaden
- Modality
- Small Molecules
- Administration
- Oral, Endoscopic
01
Overview
The intervention identified as **l-HSK Wiesbaden-Barrett's esophagus** refers to a combination therapy evaluated in the **APE-Study** (Ablation vs. Surveillance in Barrett's Esophagus), a prospective, randomized, multi-center trial led by **HSK Wiesbaden** (Horst-Schmidt-Kliniken). This regimen consists of the pharmaceutical drug **esomeprazole** and the medical procedure **argon plasma coagulation (APC)**. Esomeprazole is a proton pump inhibitor (PPI) that provides profound acid suppression by inhibiting the gastric H+/K+-ATPase enzyme. Argon plasma coagulation is a non-contact endoscopic thermal ablation technique that uses ionized argon gas to deliver high-frequency electrical current to the esophageal mucosa. The combination is specifically designed for patients previously cured of mucosal Barrett's cancer to prevent local recurrence and metachronous cancer by physically destroying metaplastic Barrett's tissue while maintaining a low-acid environment to promote healing and prevent further neoplastic progression.
- Brand names
- Nexium
- Other names
- APC plus esomeprazolethermal ablation plus esomeprazoleesomeprazole treatment + argon plasma coagulation
02
Targets
ATP4A (Potassium–transporting ATPase alpha chain 1)
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