Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
esterified butyrate
- Development stage
- Unknown
- Lead developer
- CSIRO
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Esterified butyrate, specifically delivered as butyrylated high-amylose maize starch (HAMSB), is a dietary intervention developed by the CSIRO Preventative Health National Research Flagship for the chemoprevention of colorectal cancer, particularly in patients with familial adenomatous polyposis (FAP). In this formulation, butyrate, a short-chain fatty acid (SCFA), is chemically esterified to a high-amylose maize starch backbone. This delivery system allows the butyrate to bypass the upper gastrointestinal tract and be released in the colon through bacterial fermentation of the starch. Once released, butyrate serves as a primary energy source for colonocytes and acts as a histone deacetylase (HDAC) inhibitor, promoting cell cycle arrest and apoptosis in neoplastic cells while supporting healthy colonic epithelial function.
- Other names
- butyrylated high-amylose maize starchbutyrylated starchbutyrate-esterified starch
02
Targets
FFAR2FFAR3 (Free fatty acid receptor 3)HCAR2 (Hydroxycarboxylic acid receptor 2)HDAC1 (Histone Deacetylase 1)HDAC2 (Histone deacetylase 2)HDAC3 (Histone Deacetylase 3)HDAC4HDAC8 (Histone Deacetylase 8)
Beyond the preview
Go deeper on esterified butyrate.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on esterified butyrate.