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estradiol + megestrol acetate
- Development stage
- Unknown
- Lead developer
- Chinese state research institutions
- Modality
- Small Molecules
- Administration
- Intramuscular
01
Overview
Estradiol + megestrol acetate is a **combined injectable contraceptive** used primarily in China under the names Chinese injectable No. 2 and Mego-E. Each injection contains 3.5 mg of estradiol (an estrogen) and 25 mg of megestrol acetate (a progestin, formulated as a microcrystalline aqueous suspension. It is administered by intramuscular injection once per month. This combination works by suppressing ovulation and modifying the endometrium, thus providing effective hormonal birth control. Developed and marketed in China, the product was widely distributed between 1980 and 2005–2008 but is now discontinued.
- Brand names
- Mego-EChinese injectable No. 2
- Other names
- estradiol/megestrol acetate
02
Targets
MR (Mineralocorticoid receptor)ER (Estrogen receptor)PR (Progesterone receptor)GR (Glucocorticoid receptor)
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