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estradiol + norethindrone
- Development stage
- Approved
- Lead developer
- Novo Nordisk
- Modality
- Small Molecules
- Administration
- Oral, Transdermal
01
Overview
Estradiol + norethindrone is a combination drug containing two hormones: estradiol (an estrogen) and norethindrone (a progestin). It is primarily used as hormone replacement therapy (HRT) in women with an intact uterus to treat moderate to severe symptoms of menopause, such as hot flashes, night sweats, vaginal dryness, and vulvar/vaginal atrophy. It also helps prevent postmenopausal osteoporosis. Estradiol works by replacing the estrogen that decreases during menopause, while norethindrone counteracts the risk of endometrial hyperplasia associated with unopposed estrogen therapy by providing progestin activity. The combination is available in oral tablet and transdermal patch formulations[1][2][4][6][8].
- Brand names
- ActivellaMimveyCombiPatchEstalisEstalis-SequiLopreezaAmabelz
- Other names
- estradiol and norethindrone acetate
02
Targets
ER (Estrogen receptor)PR (Progesterone receptor)
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