estradiol + sodium hyaluronate

The combination of **estradiol** and **sodium hyaluronate** is a therapeutic regimen investigated for the treatment of antibiotic-refractory recurrent urinary tract infections (rUTI) in postmenopausal women. This approach, often referred to as "Cocktail Therapy" in clinical study contexts, typically involves the local application of estrogen (estradiol) and the intravesical instillation of sodium hyaluronate. Estradiol acts as an estrogen receptor agonist to restore the urogenital epithelium and normalize the vaginal microbiome, which are often compromised in postmenopausal women. Sodium hyaluronate, a glycosaminoglycan (GAG), is instilled into the bladder to replenish the protective GAG layer of the urothelium, thereby reducing bacterial adherence and inflammatory irritation. This dual mechanism aims to address both the hormonal and structural vulnerabilities that contribute to chronic urinary tract infections.

Other names

estrogen + sodium hyaluronateCocktail Therapy