estradiol valerate + progesterone (Schering AG)

This specific hormone replacement therapy (HRT) regimen is a combination protocol used for endometrial preparation in women undergoing frozen embryo transfer (FET) as part of assisted reproductive technology (ART). The protocol, as evaluated in clinical trials by Malihe Mahmoudinia, involves the sequential administration of **estradiol valerate** and **progesterone**. Estradiol valerate is typically initiated early in the menstrual cycle to stimulate endometrial proliferation and reach an optimal thickness (≥8 mm). Once the endometrium is prepared, progesterone supplementation is introduced via vaginal suppositories and intramuscular injections to induce the secretory transformation of the endometrium, mimicking the natural luteal phase and creating a receptive environment for embryo implantation. This "artificial cycle" approach is particularly useful for patients with irregular menstrual cycles or to facilitate the scheduling of embryo transfers.

Other names

hormone replacement therapy-Malihe Mahmoudinia-infertilityArtificial Cycle FEThormone replacement therapy (HRT) groupHRT protocol for frozen embryo transfer