estrane-3,17-dione

Estrane-3,17-dione is a synthetic steroid belonging to the class of estrogens and derivatives. It is a C18 steroid with ketone groups at positions 3 and 17 on the estrane backbone. The compound exists in both (5alpha) and (5beta) stereoisomeric forms[1][8][9]. Estrane derivatives are structurally related to natural estrogens but lack significant estrogenic activity themselves; instead they serve as intermediates or metabolites in steroid biosynthesis pathways[1]. Estrane‑3,17‑dione has been studied primarily as an experimental compound and is known to act as a potent inhibitor of certain isomerase enzymes such as steroid delta-isomerase from Comamonas testosteroni[1]. There are no approved medical indications for this compound.

Other names

(5alpha)-estrane-3,17-dione5beta-estrane-3,17-dioneESR(13S)-13-methyldodecahydro-1H-cyclopenta[a]phenanthrene-3,17(2H,4H)-dione