estrogen + progesterone

The combination of estrogen and progesterone is a standard form of feminizing hormone therapy (FHT) used by transgender women to induce secondary female sex characteristics. In the context of research led by Emory University, this combination is being studied to evaluate its effects on the rectal mucosal immune environment. The primary objective is to determine if FHT alters the susceptibility of the rectal mucosa to HIV infection, which has significant implications for the optimization of biomedical HIV prevention strategies, such as Pre-Exposure Prophylaxis (PrEP) and the development of effective HIV vaccines. Estrogen and progesterone function as agonists at their respective nuclear receptors, modulating gene expression and potentially influencing mucosal barrier integrity and local immune cell populations.

Brand names

PremproCombiPatchAngeliqClimara ProActivellaBijuva

Other names

Feminizing hormone therapyFHTCombined hormone replacement therapycHRTEstrogen plus Progesterone