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eszopiclone + lemborexant
- Development stage
- Unknown
- Lead developer
- Flinders University
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
eszopiclone + lemborexant is a combination pharmacological intervention being investigated by Flinders University for the treatment of obstructive sleep apnea (OSA), specifically in patients with comorbid insomnia (COMISA) and a low arousal threshold. The combination therapy pairs eszopiclone, a GABA-A receptor positive allosteric modulator, with lemborexant, a dual orexin receptor antagonist (DORA). The therapeutic rationale is to increase the respiratory arousal threshold, preventing premature awakenings during minor airway narrowing events. By stabilizing sleep and reducing the frequency of respiratory-related arousals, the combination aims to reduce the severity of sleep apnea and improve sleep quality in this specific patient phenotype.
- Other names
- eszopiclone and lemborexant combinationeszopiclone/lemborexant
02
Targets
HCRTR1 (Orexin/hypocretin receptor type 1)HCRTR2 (Orexin/hypocretin receptor type 2)GABRR (GABA-A receptor subunit rho)
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