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etanercept + adalimumab + infliximab + certolizumab + golimumab + tozilizumab + abatacept-Medical University of Graz
- Development stage
- Unknown
- Lead developer
- Medizinische Universität Graz Open Science
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Monoclonal Antibodies → Antibody-Based Therapeutics, Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Subcutaneous, Intravenous
01
Overview
This entry refers to a specific group of biologic disease-modifying antirheumatic drugs (bDMARDs) evaluated in the clinical trial NCT01602302, conducted by the Medical University of Graz. The study, titled 'Ultrasound for bDMARD Withdrawal in RA,' investigated whether musculoskeletal ultrasound could serve as a biomarker to predict disease flares in rheumatoid arthritis patients who discontinued their biologic therapy after achieving persistent clinical remission. The group includes five TNF-alpha inhibitors (etanercept, adalimumab, infliximab, certolizumab pegol, and golimumab), an IL-6 receptor antagonist (tocilizumab), and a T-cell costimulation modulator (abatacept). These drugs represent the standard of care for patients with moderate-to-severe rheumatoid arthritis who have an inadequate response to synthetic DMARDs.
- Brand names
- CimziaActemraOrencia
- Other names
- bDMARDsbiological DMARDsbiological disease-modifying antirheumatic drugs
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))LTA (Lymphotoxin-alpha)NeuraminidaseIL-6R (Interleukin-6 receptor subunit alpha)
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