Drug intelligence / Profile preview

ethanol extract of Camellia sinensis

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

Ethanol extract of Camellia sinensis is a plant-derived preparation obtained by extracting the leaves of Camellia sinensis (commonly known as green tea) with ethanol. This extract contains a complex mixture of bioactive phytochemicals, including flavonoids and polyphenols. It has demonstrated multiple pharmacological activities in preclinical studies, notably antidiabetic effects through enhancement of insulin secretion from pancreatic β-cells via K ATP-dependent pathways, inhibition of dipeptidyl peptidase IV (DPP-IV) enzyme activity, improvement in glucose uptake and insulin action in adipocytes, and increased active glucagon-like peptide 1 (GLP-1) levels. Additional reported activities include antioxidant properties and antibacterial effects against resistant bacteria such as MRSA and STEC[1][3][4]. The main mechanisms are attributed to its diverse phytoconstituents.

Other names
EECSethanolic extract of Camellia sinensisgreen tea ethanol extract
02

Targets

DPP-4 (Dipeptidyl Peptidase-IV)KATP channel (ATP-sensitive potassium channel)GLP1R (GLP-1R)

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