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ethanol extract of cassia siamea lam leaves

Development stage
Preclinical
Administration
Oral
01

Overview

The **ethanol extract of Cassia siamea Lam leaves** is a plant-derived preparation known for a range of traditional medicinal uses, especially in Southeast Asia and Africa. Scientific studies support its potent **antidiabetic**, **antioxidant**, **anti-inflammatory**, **antimicrobial**, and **analgesic** properties. Its mechanism of action in diabetes involves both insulin-dependent and insulin-independent pathways, including **inhibition of α-amylase**, improvement of insulin sensitivity, and reduction of oxidative stress and inflammation[1][3][5]. Phytochemical screening reveals that this extract is rich in **alkaloids**, **flavonoids**, **saponins**, **triterpenoids**, **phenolic compounds**, **steroids**, and **anthraquinones**—all contributing to its pharmacological effects[1][2][3][7]. Barakol, a notable component, is credited with sedative and anxiolytic activity[2][8]. Research has shown that the extract improves glucose and insulin homeostasis, reduces hepatic inflammation, prevents vascular dysfunction, and exhibits antibacterial effects against several pathogens[3][5][7].

Other names
Cassia siamea leaf ethanol extractLECSCassia siamea Lam leaves ethanol extract
02

Targets

AMY (Pancreatic alpha-amylase)AMPK (Adenosine monophosphate–activated protein kinase)

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