Drug intelligence / Profile preview

ethinyl estradiol + norethindrone

Development stage
Approved
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral
01

Overview

Ethinyl estradiol + norethindrone is a combination oral medication containing two synthetic hormones: ethinyl estradiol (an estrogen) and norethindrone (a progestin). It is primarily used as an oral contraceptive to prevent pregnancy by inhibiting ovulation, altering cervical mucus to impede sperm penetration, and changing the endometrial lining to prevent implantation[2][3][5]. In addition to contraception, certain formulations are approved for hormone replacement therapy (HRT) in menopausal women, where they alleviate symptoms such as hot flashes and vaginal dryness and help prevent osteoporosis by supplementing estrogen levels[4][8]. The mechanism of action involves agonism at the estrogen receptor (ethinyl estradiol) and progesterone receptor (norethindrone), mimicking endogenous female sex hormones.

Brand names
Loestrin 24 FeLoestrin24 FeLoestrin-24 FeLoestrin Fe 1.5/30Loestrin Fe 1/20Lo Loestrin FeLomedia 24 FeLomedia24 FeLomedia-24 FeLo Minastrin FeEstrostep FeGildess Fe 1.5/30Gildess Fe 1/20Junel Fe 1.5/30Junel Fe 1/20Junel Fe 24Microgestin Fe 1.5/30Microgestin Fe 1/20Minastrin 24 FEMinastrin24 FEMinastrin-24 FETilia FeTriLegest FeBlisovi 24 FeBlisovi24 FeBlisovi-24 FeBlisovi Fe 1.5/30Blisovi Fe 1/20TaytullaLarin 24 FELarin24 FELarin-24 FELarin FE 1/20Larin FE 1.5/30Melodetta 24 FEMelodetta24 FEMelodetta-24 FEMibelas 24 FEMibelas24 FEMibelas-24 FETarina 24 FETarina24 FETarina-24 FETarina 24 FETarina FE 1/20MerzeeFyavolvJinteliJevantique Lo HRT
Other names
norethindrone acetate + ethinyl estradiol
02

Targets

PR (Progesterone receptor)ESR2 (ERβ)ESR1 (ERα)

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