ethinylestradiol + drospirenone (Gedeon Richter Plc)

Daylette is a combined oral contraceptive (COC) containing the synthetic estrogen ethinylestradiol and the fourth-generation progestogen drospirenone. It is typically administered in a 24+4 regimen, consisting of 24 active film-coated tablets followed by 4 inactive placebo tablets. Drospirenone is unique among progestins for its anti-androgenic and anti-mineralocorticoid properties, which help mitigate common estrogen-related side effects like water retention and are beneficial in treating androgen-dependent conditions such as acne and hirsutism. The primary mechanism of action is the suppression of gonadotropins, which inhibits ovulation, increases cervical mucus viscosity to impede sperm penetration, and alters the endometrium to prevent implantation. Daylette is widely used for the prevention of pregnancy and is also investigated for its comprehensive health effects in women with polycystic ovary syndrome (PCOS).

Brand names

Daylette