ethyl acetate fraction of Boehmeria nivea

The ethyl acetate fraction of Boehmeria nivea (EA-BN) is a plant extract-based herbal medicine under investigation for the treatment of allergic asthma. Derived from the ramie plant (Urticaceae family), EA-BN is administered orally and exerts its therapeutic effects by modulating the immune response. Its mechanism of action involves the suppression of dendritic cell activation and the inhibition of T-helper 2 (Th2) cell differentiation. This inhibition is achieved by reducing the expression of the transcription factor GATA-3, which subsequently downregulates the production of Th2-associated cytokines such as IL-4, IL-5, and IL-13. Preclinical studies in mouse models have demonstrated that EA-BN significantly reduces airway inflammation, mucus overproduction, and inflammatory cell infiltration. The research is primarily led by the Korea Research Institute of Bioscience and Biotechnology (KRIBB).

Other names

Boehmeria nivea ethyl acetate fractionramie ethyl acetate fraction