ethyl loflazepate

Ethyl loflazepate is a benzodiazepine derivative used primarily as an anxiolytic and sedative. It also possesses anticonvulsant and skeletal muscle relaxant properties. Ethyl loflazepate acts as a prodrug, with its main pharmacological effects mediated by its active metabolite, descarboxyloflazepate, which is a benzodiazepine receptor agonist. The drug exerts its effects by acting as a positive allosteric modulator of the GABA-A receptor complex, enhancing the inhibitory neurotransmitter GABA's effect in the central nervous system. It has been approved for use in conditions such as anxiety (including post-trauma anxiety), generalized anxiety disorder (GAD), panic attacks, obsessive–compulsive disorder, delirium tremens, and anxiety associated with severe neuropathic pain[1][5][6]. Ethyl loflazepate is not approved for marketing in the United States but is commercialized under various brand names in other countries.

Brand names

MeilaxRonlaxVictan

Other names

ethyl loflazepateethyl fluclozepateethyl flucozepate