eticlopride

Eticlopride is a substituted benzamide analog and a highly selective antagonist of dopamine D2-like receptors (primarily D2 and D3 subtypes). It was initially developed as a potential antipsychotic agent but is not used clinically. Instead, eticlopride has become an important research tool for studying central dopamine receptor function, the behavioral roles of D2-like receptors, and the effects of their blockade in preclinical animal models. It exhibits high affinity for both dopamine D2 (Ki ≈ 0.50 nM) and D3 (Ki ≈ 0.16 nM) receptors and demonstrates potent antipsychotic activity in animal studies[1][4][5][6]. Eticlopride is widely used in vivo, in vitro, and ex vivo to examine dopamine receptor densities and functions[4]. Its structure features an ethyl group at the aromatic 5-position and a chlorine at the aromatic 3-position on its benzamide core[1].

Other names

EticlopridaEticlopridum3-chloro-5-ethyl-N-(1-ethyl-pyrrolidin-2-ylmethyl)-6-hydroxy-2-methoxy-benzamide84226-12-0