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Drug intelligence / Profile preview
Etizest-plus
- Development stage
- Unknown
- Lead developer
- Consern Pharma
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Etizest-plus is a combination pharmaceutical product manufactured by Apgar Pharmaceuticals, primarily indicated for the treatment of comorbid depression and anxiety disorders. It consists of two active small molecule ingredients: etizolam and escitalopram. Etizolam is a thienodiazepine that acts as a positive allosteric modulator of the GABA-A receptor, providing rapid anxiolytic, sedative, and muscle relaxant effects. Escitalopram is a selective serotonin reuptake inhibitor (SSRI) that increases synaptic serotonin levels by inhibiting the serotonin transporter (SERT), addressing underlying depressive symptoms and providing long-term management of mood disorders. This combination is designed to offer both immediate relief of acute anxiety symptoms and sustained therapeutic benefit for neuropsychiatric conditions.
- Brand names
- Etizest-plus
- Other names
- Etizolam + Escitalopram
02
Targets
BZD site (GABA-A receptor benzodiazepine site)PTAFR (Platelet-activating factor receptor)SERT (Sodium-dependent serotonin transporter)GABRA1 (Gamma-aminobutyric acid type A receptor alpha 1 subunit)
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