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etoposide + anlotinib
- Development stage
- Phase 2
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A combination therapy consisting of etoposide, a topoisomerase II inhibitor chemotherapy agent, and anlotinib, a multi-target tyrosine kinase inhibitor that primarily inhibits angiogenesis, with anti-angiogenic properties. This combination has been studied in various cancer indications, particularly for extensive-stage small-cell lung cancer (ES-SCLC) and advanced non-small cell lung cancer (NSCLC). The combination can be administered orally, making it more convenient for patients compared to intravenous chemotherapy regimens.
02
Targets
FGFR1 (Fibroblast growth factor receptor 1)FGFR2 (Keratinocyte growth factor receptor)FGFR3 (Fibroblast growth factor receptor 3)FGFR4 (Fibroblast growth factor receptor 4)PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)TOP2A (DNA topoisomerase II)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)FGFR (FGFR family)
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