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etoposide + thioguanine + cyclophosphamide + busulfan + melphalan
- Development stage
- Unknown
- Lead developer
- Dutch Childhood Oncology Group
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
This intensive multi-agent chemotherapy combination consists of etoposide, thioguanine, cyclophosphamide, busulfan, and melphalan. It was evaluated by the Dutch Childhood Oncology Group (DCOG) as a conditioning or intensive re-induction regimen for pediatric and adolescent patients with relapsed or refractory acute myeloid leukemia (AML). The regimen leverages multiple cytotoxic pathways: etoposide inhibits DNA topoisomerase II; thioguanine acts as a purine antimetabolite; and cyclophosphamide, busulfan, and melphalan serve as potent DNA alkylating agents. This combination is designed to overcome multi-drug resistance in aggressive myeloid leukemias, often serving as a bridge to hematopoietic stem cell transplantation.
- Other names
- Etoposide/Thioguanine/Cyclophosphamide/Busulfan/Melphalan
02
Targets
DNATOP2A (DNA topoisomerase II)
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