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ETT1 siRNA
- Development stage
- Preclinical
- Lead developer
- Universitätsklinikum Leipzig
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Subcutaneous, Intravenous
01
Overview
ETT1 siRNA is a small interfering RNA therapeutic candidate designed to silence the expression of Endothelial TMAO Transporter 1 (ETT1). ETT1 is a solute carrier protein identified in endothelial cells that facilitates the uptake of trimethylamine N-oxide (TMAO), a gut-derived metabolite associated with cardiovascular risk. By inhibiting ETT1 expression, the siRNA prevents TMAO-induced inflammatory activation and endothelial-to-mesenchymal transition (EndMT), processes that contribute to the development of atherosclerosis and vascular impairment.
02
Targets
SLC superfamily (Solute carrier superfamily)
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