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etzadroxil
- Development stage
- Unknown
- Lead developer
- Iterum Therapeutics
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Etzadroxil is a prodrug moiety that is chemically linked to active pharmaceutical ingredients, such as sulopenem and ledaborbactam, to improve their oral bioavailability. It is hydrolyzed in the body to release the active drug.
02
Targets
PBP1A (Penicillin-binding protein 1A)PBP4 (Penicillin-binding protein 4)PBP1b (Penicillin-binding protein 1B)PBP5 (D-alanyl-D-alanine carboxypeptidase DacA)PBP2 (Penicillin-binding protein 2)
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