euphorbia fischeriana root extract

Euphorbia fischeriana root extract is a traditional Chinese medicine derived from the roots of the perennial herb *Euphorbia fischeriana* Steud (Euphorbiaceae). The extract contains multiple bioactive constituents including **ent-abietane diterpenoids** (the main active constituents), **ent-atisane diterpenoids**, **ent-kauranes**, **ent-isopimaranes**, **ent-pimaranes**, **triterpenoids**, **meroterpenoids**, **acetophenones**, **flavonoids**, **coumarins**, **steroids**, **phenolic acids**, **tannins**, and **alkaloids**[1][2][3]. The extract has demonstrated significant **anticancer activity** against multiple cancer cell lines, including prostate cancer (C4-2B and C4-2B/ENZR), breast cancer (MCF-7, ZR-75-1, MDA-MB-231), and melanoma (B16 cells)[1][2][5]. Key bioactive compounds include jolkinolide A and B, 17-hydroxyjolkinolide A and B, and various euphonoid compounds. The extract exhibits multiple pharmacological activities including **anti-tumor**, **antibacterial**, **anti-inflammatory**, **antiviral** (including anti-SARS-CoV-2 activity), and **anti-leukemia** effects[3][7]. Traditional uses include treatment of tuberculosis, ringworm, lymphoid tuberculosis, edema, ascites, cough, dyspepsia, abdominal distension, and external applications for scabies[1][3]. The extract is typically prepared using ethanol extraction methods, with typical preparations containing approximately 0.53% jolkinolides, 1.06% fischeriana compounds, and 1.75% flavonoids[5].

Other names

E. fischeriana root extractEuphorbia fischeriana Steud root extract