euphorbia prostrata extract

**Euphorbia prostrata extract** is a standardized dry extract derived from the aerial parts of the plant *Euphorbia prostrata* (family Euphorbiaceae), approved in India since 2008 as a drug of modern medicine for hemorrhoidal disease. Rich in flavonoids (e.g., apigenin, luteolin, quercetin-3-O-glucoside, kaempferol-3-O-rutinoside), phenolic acids (e.g., gallic acid, ellagic acid, caffeic acid), tannins, and terpenoids (e.g., β-amyrin, taraxerol), it exerts multimodal pharmacological effects including anti-inflammatory, antioxidant, venotonic, hemostatic, astringent, wound-healing, and vasoprotective actions. These properties target hemorrhoidal pathogenesis by enhancing noradrenaline-induced vasoconstriction, improving venous wall elasticity, reducing capillary permeability, scavenging free radicals, inhibiting NF-κB-mediated cytokine production, and promoting mucosal toughening. Available as 100 mg oral tablets (often twice daily for 14 days), 1% topical cream, or fixed-dose combinations (e.g., with calcium dobesilate or lidocaine), it provides rapid symptom relief in grades 1-4 hemorrhoids, including post-hemorrhoidectomy, with established clinical efficacy and safety in observational studies and trials involving thousands of patients. Patented in India, US, and Europe for anorectal and colonic diseases.[1][5][7][9]

Brand names

SitcomThank OD

Other names

euphorbia prostrataprostrate spurgetrailing red spurge