Eurotium amstelodami

*Eurotium amstelodami* is a xerophilic fungus traditionally recognized as a common spoilage organism in low-moisture foods and animal feeds. In a biomedical context, it is identified as one of the primary etiological agents of Farmer's Lung Disease (FLD), a form of hypersensitivity pneumonitis; consequently, its purified and recombinant antigens are utilized in standardized serological diagnostic ELISA tests. Recent preclinical research has explored its potential as a probiotic fungus, demonstrating protective effects against dextran sulfate sodium (DSS)-induced ulcerative colitis and gut-derived liver injury in murine models. The proposed mechanism involves the modulation of gut microbial community structure, restoration of bile acid metabolism via the farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5), and the suppression of inflammatory pathways including TLR4/NF-kB and the NLRP3 inflammasome. Additionally, *E. amstelodami* is utilized in the fermentation of specialty teas (such as Fuzhuan brick tea) and high-temperature Daqu, where it facilitates the bioconversion of flavonoid glycosides into bioactive aglycones and produces secondary metabolites like asperflavin with anti-inflammatory properties.

Other names

Aspergillus amstelodami